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KMID : 0379520080240010017
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한국독성학회지
2008 Volume.24 No. 1 p.17 ~ p.22
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Inhibition of Dermatitis Development by Sopungsan in Nc/Nga Mice
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Pokharel Yuba Raj
Lim Sung-Chul
Kim Sang-Chan
Choi Hu Kyun
Kang Keon-Wook
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Abstract
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Sopungsan (SS) is a traditional Korean decoction used for the treatment of dermatitis. The aim of this study is to confirm whether or not SS has a preventive effect on the development of atopic dermatitis in dinitrochlorobenzene-applied Nc/Nga mice. SS was administered orally to Nc/Nga mice, which led to the remarkable suppression of the development of dermatitis, as determined by a histological examination and the serum IgE levels. Moreover, SS inhibited the production of thymus- and activation-regulated chemokine (TARC) and its mRNA expression in a keratinocyte cell line, HaCaT, which had been stimulated with tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). Activation of the nuclear factor-κB (NF-κB) or activator protein-1 (AP-1) is one of key steps in the signaling pathways mediating induction of TARC. In this study, SS selectively suppressed NF-κB activation which may be essential for TARC expression in TNF-α/IFN-γ treated keratinocytes. The inhibitory effect of SS on NF-κB activation and TARC production might be associated with the anti-dermatitic effects of SS.
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KEYWORD
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Atopic dermatitis, Anti-dermatitic activity, NF-κB, Sopungsan, TARC
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